單分散小分子量,羧基PEG羥基,HO-PEGn-CH2COOH

單分散小分子量,羧基PEG羥基,HO-PEGn-CH2COOH

HO-PEG2-CH2COOH

  • 產品別名:HO-PEG2-CH2COOH
  • CAS No:51951-04-3
  • M.F.:C6H12O5
  • M.W.:164.15
  • 儲存條件:4 ℃ for long term storage
  • 產品純度:>97.00%

HO-PEG4-CH2COOH

  • 產品別名:HO-PEG4-CH2COOH
  • CAS No:70678-95-4
  • M.F.:C10H20O7
  • M.W.:252.25
  • 儲存條件:4 ℃ for long term storage
  • 產品純度:>97.00%
  • 產品性狀:

HO-PEG6-CH2COOH

  • 產品別名:HO-PEG6-CH2COOH
  • CAS No:120394-66-3
  • M.F.:C14H28O9
  • M.W.:340.35
  • 儲存條件:4 ℃ for long term storage
  • 產品純度:>97.00%

HO-PEG8-CH2COOH

  • 產品別名:HO-PEG8-CH2COOH
  • CAS No:780006-30-6
  • M.F.:C18H36O11
  • M.W.:428.45
  • 儲存條件:4 ℃ for long term storage
  • 產品純度:>97.00%
Product Name CAS No Structure
HO-PEG2-CH2COOH 51951-04-3 HO-PEG<sub>2</sub>-CH<sub>2</sub>COOH
HO-PEG4-CH2COOH 70678-95-4 HO-PEG<sub>4</sub>-CH<sub>2</sub>COOH
HO-PEG6-CH2COOH 120394-66-3 HO-PEG<sub>6</sub>-CH<sub>2</sub>COOH
HO-PEG8-CH2COOH 780006-30-6 HO-PEG<sub>8</sub>-CH<sub>2</sub>COOH
HO-PEG10-CH2COOH N/A HO-PEG<sub>10</sub>-CH<sub>2</sub>COOH
HO-PEG12-CH2COOH N/A HO-PEG<sub>12</sub>-CH<sub>2</sub>COOH
HO-PEG24-CH2COOH N/A HO-PEG<sub>24</sub>-CH<sub>2</sub>COOH

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單分散小分子量,羧基PEG羥基,HO-PEGn-CH2COOH

單分散小分子量,羧基PEG羥基,HO-PEGn-CH2COOH

HO-PEG2-CH2COOH

  • 產品別名:HO-PEG2-CH2COOH
  • CAS No:51951-04-3
  • M.F.:C6H12O5
  • M.W.:164.15
  • 儲存條件:4 ℃ for long term storage
  • 產品純度:>97.00%

HO-PEG4-CH2COOH

  • 產品別名:HO-PEG4-CH2COOH
  • CAS No:70678-95-4
  • M.F.:C10H20O7
  • M.W.:252.25
  • 儲存條件:4 ℃ for long term storage
  • 產品純度:>97.00%
  • 產品性狀:

HO-PEG6-CH2COOH

  • 產品別名:HO-PEG6-CH2COOH
  • CAS No:120394-66-3
  • M.F.:C14H28O9
  • M.W.:340.35
  • 儲存條件:4 ℃ for long term storage
  • 產品純度:>97.00%

HO-PEG8-CH2COOH

  • 產品別名:HO-PEG8-CH2COOH
  • CAS No:780006-30-6
  • M.F.:C18H36O11
  • M.W.:428.45
  • 儲存條件:4 ℃ for long term storage
  • 產品純度:>97.00%
Product Name CAS No Structure
HO-PEG2-CH2COOH 51951-04-3 HO-PEG<sub>2</sub>-CH<sub>2</sub>COOH
HO-PEG4-CH2COOH 70678-95-4 HO-PEG<sub>4</sub>-CH<sub>2</sub>COOH
HO-PEG6-CH2COOH 120394-66-3 HO-PEG<sub>6</sub>-CH<sub>2</sub>COOH
HO-PEG8-CH2COOH 780006-30-6 HO-PEG<sub>8</sub>-CH<sub>2</sub>COOH
HO-PEG10-CH2COOH N/A HO-PEG<sub>10</sub>-CH<sub>2</sub>COOH
HO-PEG12-CH2COOH N/A HO-PEG<sub>12</sub>-CH<sub>2</sub>COOH
HO-PEG24-CH2COOH N/A HO-PEG<sub>24</sub>-CH<sub>2</sub>COOH

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單分散修飾性PEG、小分子量PEG介紹

單分散修飾性PEG、小分子量PEG介紹

聚乙二醇化技術(PEGylation)是一種先進的藥用大分子修飾技術。聚乙二醇分子與藥物分子連接,能夠增大藥物的相對分子量,達到延長藥效,降低毒性,增大藥物的水溶性等效果,聚乙二醇化技術(PEGylation)是改善藥物臨床效果的重要手段。

Monodisperse PEG(單分散修飾性PEG)的產品一般是由2個、3個、4個PEG重復單元組成的一種小分子單分散的純的PEG試劑,這類產品的整體分子量較小,他們的分子量的大小跟PEG的重復個數有關,個數越多分子量越大,由于此產品是重復單元的PEG屬于小分子單體,可以用純度來標明其質量的好壞,西安瑞禧生物生產的這種產品整體純度一般是95%+以上。該類小分子聚合物的重復單元一般從1個到24個之間不等,PEG二邊也常常存在的不同的基團,比如說羧基COOH,NH2氨基,N3疊氮,巰基SH等不同基團。當然由于該類產品是純的小分子,大部分產品都對應的有自己的CAS號。

小分子聚乙二醇(PEG)鏈接劑,可用于修飾各類生物藥物,通過正離子親脂類脂質體納米顆粒形成配方材料,將可能即時裝載靶向分子、實現對任何藥物的掛載,可為建立針對腫瘤患者的個性化治療藥物庫提供成熟的技術支持。

單分散短鏈小分子PEG

修飾性PEG品牌:金畔生物、Laysan Bio、Nanocs、Sunbio

polymer PEG衍生物產品一般是指以聚合物的聚乙二醇為原料,通過各種化學鍵反應,使得聚合物PEG二邊連上不同的活性基團,該類的產品的分子量都比較大,主要也取決于PEG的分子量的大學,比如說PEG分子量1000,那整體分子量就是1000多一點,如果PEG分子量是2000就是2000多一點,另外整體也看連接的基團,比如說PEG分子量是2000 ,他連接了DSPE這個基團,那整體分子量就是2800,如果連接了MAL或者NH2這樣的基團,這題分子量就是2100多,該類產品的質量不能按純度來衡量,因而PEG是聚合物,整個產品都是有一個分子量的分布的,所以該產品應該屬于混合物,我們衡量其質量一般看2個指標一個是PDI值,一個是取代率純度或者叫接枝率,PID值越小PEG的分布越窄,質量越好,取代率純度或接枝率越高 說明活性基團和PEG的鏈接率越高。該類產品沒有固定的CAS號 因為是聚合物。

另外還有一種polymer PEG產品是由二種或者2種以上的聚合物鏈接而成的,我們常常叫嵌段共聚物,A聚合物、B聚合物、C聚合物,我們常見的形式有A-B-A,B-A-B, A-B-C,A-B-C-A

等等,這類產品我們常用的聚合物一般有PEG、PLGA、PLA、PCL、PEI、PLL等等不同產品,往往可以在不同聚合物末端帶有不同的活性基團比如說MAL/NHS/COOH等等。

單分散修飾性PEG、小分子量PEG介紹

Monodisperse PEG小分子PEG產品列表:

Amine-PEG2-Acid??? 791028-27-8 ? ?氨基PEG羧基,氨基聚乙二醇羧基

Amine-PEG3-Acid??? 784105-33-5

Amine-PEG4-Acid??? 663921-15-1

Amine-PEG6-Acid??? 905954-28-1

Amine-PEG8-Acid??? 756526-04-2

 

Thiol-PEG4-Acid? 749247-06-1

Thiol-PEG5-Acid

Thiol-PEG8-Acid? 866889-02-3

Thiol-PEG12-Acid 1032347-93-5

 

MAL-PEG2-Acid?? ?756525-98-1

MAL-PEG3-Acid??? 518044-40-1

MAL-PEG4-Acid??? 518044-41-2

MAL-PEG5-Acid??? 1286755-26-7

MAL-PEG6-Acid??? 518044-42-3

MAL-PEG8-Acid??? 1818294-46-0

 

Azido-PEG2-Azide????? 1379365-47-5

Azido-PEG3-azide????? 101187-39-7

Azido-PEG4-Azide????? 182760-73-2

Azido-PEG5-Azide????? 356046-26-9

 

Biotin-PEG2-Acid??????? 1365655-89-5

Biotin-PEG3-acid??????? 252881-76-8

Biotin-PEG4-Acid??????? 721431-18-1

Biotin-PEG6-Acid??????? 1352814-10-8

Biotin-PEG12-Acid????? 1621423-14-0

 

Fmoc-NH-PEG2-CH2COOH???? 166108-71-0

Fmoc-NH-PEG2-CH2COOH???? 166108-71-0

Fmoc-NH-PEG3-CH2COOH???? 139338-72-0

Fmoc-NH-PEG4-CH2CO2H????? 437655-95-3

Fmoc-NH-PEG5-CH2COOH???? 635287-26-2

Fmoc-NH-PEG8-CH2COOH???? 868594-52-9

 

Fmoc-PEG4-NHS ester???? 1314378-14-7

Fmoc-PEG6-NHS ester???? 1818294-31-3

Fmoc-PEG8-NHS ester???? 1334170-03-4

 

t-Boc-N-amido-PEG2-acid???????? 1365655-91-9

t-Boc-N-amido-PEG3-acid???????? 1347750-75-7

t-Boc-N-amido-PEG4-acid???????? 756525-91-4

t-Boc-N-amido-PEG5-acid???????? 1347750-78-0

t-Boc-N-amido-PEG6-acid???????? 882847-13-4

t-Boc-N-amido-PEG8-acid???????? 1334169-93-5

t-Boc-N-amido-PEG12-acid?????? 187848-68-6

 

t-Boc-N-amido-PEG2-Amine???? 153086-78-3

t-Boc-N-Amido-PEG3-Amine???? 101187-40-0

t-Boc-N-amido-PEG4-Amine???? 811442-84-9

t-boc-N-amido-PEG5-Amine???? 189209-27-6

t-Boc-N-amido-PEG6-Amine???? 1091627-77-8

t-boc-N-amido-PEG7-Amine???? 206265-98-7

t-Boc-N-amido-PEG9-Amine???? 890091-43-7

t-Boc-N-amido-PEG11-Amine?? 890091-42-6

 

t-Boc-N-Amido-PEG2-Azide????? 950683-55-3

t-Boc-N-Amido-PEG3-Azide????? 642091-68-7

t-Boc-N-Amido-PEG4-Azide????? 940951-99-5

t-boc-N-amido-PEG5-Azide????? 189209-27-6

 

mPEG2-NH2? 31576-51-9

mPEG3-NH2? 74654-07-2

mPEG4-NH2? 85030-56-4

mPEG6-NH2? 5498-83-9

mPEG8-NH2? 184357-46-8?? 170572-38-0? 211859-73-3

mPEG9-NH2

mPEG10-NH2??? 854601-60-8

mPEG12-NH2??? 869718-87-6

 

mPEG3-COOH?? 67319-28-2

mPEG4-COOH?? 81836-43-3

mPEG5-COOH

mPEG6-COOH?? 874208-91-0

mPEG7-COOH?? 1093647-41-6

 

mPEG3-SH?? 31521-83-2

mPEG4-SH?? 52190-55-3??? 524030-00-0

mPEG6-SH?? 441771-60-4

mPEG8-SH?? 651042-83-0

mPEG9-SH?? 651042-84-1

mPEG10-SH? 651042-85-2

SPDP-PEG3-acid??????? 1334177-97-7

SPDP-PEG6-acid??????? 1818294-33-5

 

Biotin-PEG3-alcohol??? 1263044-40-1

Biotin-PEG4-alcohol??? 1778736-18-7

Biotin-PEG6-alcohol??? 906099-89-6

 

Biotin-PEG4-Alkyne??? 1458576-00-5

 

Biotin-PEG2-Amine???? 138529-46-1

Biotin-PEG3-Amine???? 359860-27-8

Biotin-PEG4-Amine???? 663171-32-2

Biotin-PEG5-Amine???? 113072-75-6

 

Biotin-PEG2-Azide

Biotin-PEG3-Azide????? 945633-30-7

Biotin-PEG4-Azide????? 875770-34-6

Biotin-PEG5-azide????? 1163732-89-5

Biotin-PEG7-Azide????? 1334172-75-6

 

NH2-PEG3-NH2??? 929-75-9

NH2-PEG4-NH2??? 68960-97-4

NH2-PEG5-NH2??? 72236-26-1

NH2-PEG6-NH2

NH2-PEG7-NH2

NH2-PEG8-NH2??? 822096-36-7

NH2-PEG9-NH2

NH2-PEG10-NH2??? 928292-69-7

 

 

HOOC-PEG3-COOH??? 31127-85-2

HOOC-PEG4-COOH??? 439114-13-3

HOOC-PEG6-COOH??? 94376-75-7

 

HO-PEG6-COOH?? 1347750-85-9

HO-PEG8-COOH?? 937188-60-8

 

MAL-PEG2-NHS??? 1433997-01-3

MAL-PEG3-NHS??? 1537892-36-6

MAL-PEG4-NHS??? 1325208-25-0

MAL-PEG5-NHS??? 1807537-42-3

MAL-PEG6-NHS???? 1599472-25-9

 

H2N-PEG3-OH?? 86770-74-3

H2N-PEG4-OH

H2N-PEG5-OH?? 34188-11-9

H2N-PEG6-OH?? 39160-70-8

H2N-PEG7-OH?? 1425973-14-3

H2N-PEG8-OH?? 352439-37-3

H2N-PEG12-OH?? 933789-97-0

 

N3-PEG2-NH2?? 166388-57-4

N3-PEG3-NH2?? 134179-38-7

N3-PEG4-NH2?? 951671-92-4

N3-PEG5-NH2?? 516493-93-9

N3-PEG6-NH2?? 957486-82-7

N3-PEG7-NH2? 1333154-77-0

N3-PEG8-NH2? 857891-82-8

N3-PEG10-NH2? 912849-73-1

 

N3-PEG2-NHS?? 29885-96-9

N3-PEG3-NHS?? 1245718-89-1

N3-PEG4-NHS?? 944251-24-5

N3-PEG5-NHS?? 1433996-86-1

N3-PEG8-NHS?? 1204834-00-3

N3-PEG12-NHS? 1610796-02-5

 

N3-PEG2-OH??? 139115-90-5

N3-PEG3-OH??? 86520-52-7

N3-PEG4-OH??? 86770-67-4

N3-PEG5-OH?? 86770-68-5

N3-PEG6-OH?? 86770-69-6

 

N3-PEG2-COOH? 1312309-63-9

N3-PEG3-COOH? 172531-37-2

N3-PEG4-COOH? 1257063-35-6

N3-PEG5-COOH? 1425973-16-5

N3-PEG6-COOH? 361189-66-4

N3-PEG8-COOH? 1214319-92-2

N3-PEG10-COOH? 1644163-57-4

N3-PEG12-COOH ?1167575-20-3

 

Biotin-PEG2-NH2? 138529-46-1

Biotin-PEG3-NH2? 359860-27-8

Biotin-PEG4-NH2?? 138529-46-1

Biotin-PEG5-NH2?? 113072-75-6

Biotin-PEG6-NH2?? 663171-32-2

Biotin-PEG7-NH2?? 1334172-76-7

 

Biotin-PEG2-COOH ??1365655-89-5

Biotin-PEG3-COOH ???252881-76-8

Biotin-PEG4-COOH?? 721431-18-1

Biotin-PEG6-COOH?? 1352814-10-8

Biotin-PEG8-COOH

Biotin-PEG12-COOH?? 1621423-14-0

 

Biotin-PEG3-NHS??? 596820-83-6

Biotin-PEG3-NHS??? 1253286-56-4

Biotin-PEG4-NHS??? 459426-22-3

Biotin-PEG6-NHS

Biotin-PEG8-NHS

Biotin-PEG12-NHS?? 365441-71-0

Biotin-PEG20-NHS

Biotin-PEG24-NHS

 

Biotin-PEG3-N3?? 945633-30-7

Biotin-PEG4-N3?? 875770-34-6

Biotin-PEG5-N3?? 1163732-89-5

Biotin-PEG7-N3?? 1334172-75-6

 

Biotin-PEG2-MAL? 305372-39-8

Biotin-PEG3-MAL? 1431618-70-0

Biotin-PEG6-MAL? 1808990-66-0

 

Biotin-PEG4-Alkyne? 1458576-00-5

 

Fluorescein-PEG4-Acid?? 1807518-76-8

Fluorescein-PEG6-Acid

Fluorescein-PEG3-Amine? 1807539-04-3

Fluorescein-PEG2-Azide?? 1146195-72-3

Fluorescein-PEG3-(N-Boc)-Amine?? 1807534-77-5

Fluorescein-PEG6-NHS ester?????? 1818294-35-7

TAMRA-PEG3-Azide??? 1228100-59-1

TAMRA-PEG4-Alkyne?? 1225057-68-0

TAMRA-Azide-PEG-Biotin

TAMRA-PEG4-DBCO

Pyrene -PEG4-acid

Pyrene -PEG2-azide

Cy5-PEG4-acid

 

Mal-PEG2-PFP??? 1807512-47-5

Mal-PEG3-PFP??? 1807534-78-6

Mal-PEG4-PFP??? 1415800-42-8

Mal-PEG5-PFP??? 1807512-46-4

Mal-PEG6-PFP??? 1599486-33-5

 

Azide-PEG3-Tos? 178685-33-1

Azide-PEG4-Tos? 236754-49-7

Azide-PEG5-Tos? 236754-49-7

 

Hydroxy-PEG3-Tos?????? 77544-68-4

Hydroxy-PEG4-Tos?????? 77544-68-4

Hydroxy-PEG5-Tos?????? 77544-60-6

Hydroxy-PEG6-Tos?????? 155130-15-7

 

Propargyl-PEG4-Tos?? 875770-32-4

Propargyl-PEG5-Tos?? 875770-32-4

 

Azido-PEG3-Maleimide

 

Bromo-PEG2-azide???? 530151-56-5

Bromo-PEG3-azide???? 940005-81-2

Bromo-PEG5-azide???? 1415800-37-1

 

Azido-PEG2-TFP ester????? 1807534-87-7

Azido-PEG3-TFP ester????? 1807540-76-6

Azido-PEG4-TFP ester????? 1807505-33-4

Azido-PEG5-TFP ester????? 1807505-31-2

Azido-PEG6-TFP ester????? 1818294-50-6

Azido-PEG8-TFP ester????? 1818294-49-3

 

Azido-PEG2-PFP ester????? 1393330-37-4

Azido-PEG3-PFP ester????? 1807530-07-9

Azido-PEG4-PFP ester????? 1353012-00-6

Azido-PEG5-PFP ester????? 1818294-48-2

Azido-PEG6-PFP ester????? 1818294-47-1

 

DBCO-PEG4-acid?????? 1537170-85-6

DBCO-PEG5-Acid

DBCO-PEG4-Alcohol

DBCO-amine??????? 1255942-06-3

DBCO-PEG4-amine??? 1255942-08-5

DBCO-PEG4-Biotin???? 1255942-07-4

DBCO-PEG4-Maleimide???? 1480516-75-3

DBCO-PEG4-NHS ester??? 1427004-19-0

DBCO-PEG5-NHS ester??? 1378531-80-6

 

DNP-PEG2-acid?? 1353011-89-8

DNP-PEG4-acid?? 858126-76-8

DNP-PEG6-acid?? 1817829-84-7

DNP-PEG4-NHS ester?????? 858126-78-0

 

propargyl-PEG3-Acid? 1347760-82-0

Propargyl-PEG4-acid? 1415800-32-6

propargyl-PEG5-Acid? 1245823-51-1

 

Propargyl-PEG2-amine????? 944561-44-8

Propargyl-PEG3-amine????? 932741-18-9

Propargyl-PEG4-amine????? 1013921-36-2

Propargyl-PEG5-amine????? 1589522-46-2

Propargyl-PEG6-amine????? 1198080-04-4

 

Propargyl-PEG3-azide????????????? 932741-18-9

 

Propargyl-PEG4-Maleimide?????? 1609651-90-2

 

Propargyl-PEG3-NHS ester????? 1428629-71-3

Propargyl-PEG4-NHS ester????? 1428629-70-2

Propargyl-PEG5-NHS ester????? 1393330-40-9

 

DBCO-PEG4-Biotin???? 1255942-07-4

 

Biotin-PEG3-hydrazide????? 1381861-94-4

 

Bis-PEG2-acid???? 19364-66-0

Bis-PEG3-acid???? 96517-92-9

Bis-PEG4-acid???? 31127-85-2

Bis-PEG5-acid???? 439114-13-3

Bis-PEG7-acid???? 94376-75-7

Bis-PEG9-acid???? 1268488-70-5

 

Acid-PEG5-NHS ester????????????? 1343476-41-4

 

Bis-PEG2-NHS Ester???????? 65869-63-8

Bis-PEG3-NHS Ester???????? 1314378-16-9

Bis-PEG4-NHS ester???????? 1314378-11-4

Bis-PEG5-NHS ester???????? 756526-03-1

Bis-PEG6-NHS ester???????? 1526718-98-8

Bis-PEG7-NHS ester???????? 1334170-02-3

 

TCO-PEG4-Acid???????? 1802913-21-8

TCO-PEG3-Maleimide?????? 1609659-01-9

TCO-NHS ester????????? 1191901-33-3

TCO-PEG4-NHS ester?????? 1613439-69-2

 

Hydroxy-PEG2-acid??? 1334286-77-9

Hydroxy-PEG3-acid??? 518044-49-0

Hydroxy-PEG4-acid??? 937188-59-5

Hydroxy-PEG6-acid??? 1347750-85-9

Hydroxy-PEG8-t-butyl ester????? 937188-60-8

 

Amino-PEG3-alcohol?? 6338-55-2

Amino-PEG4-alcohol?? 86770-74-3

Amino-PEG5-alcohol?? 34188-11-9

Amino-PEG6-alcohol?? 39160-70-8

Amino-PEG7-alcohol?? 1425973-14-3

Amino-PEG8-alcohol?? 352439-37-3

Amino-PEG12-alcohol 933789-97-0

 

Methyltetrazine-PEG4-Acid?????? 1802907-91-0

Methyltetrazine-PEG5-Alkyne?? 1802907-97-6

Methyltetrazine-PEG4-Amine??? 1802908-05-9

Biotin-PEG4-Methyltetrazine???? 1835759-81-3

Methyltetrazine-PEG4-Maleimide???? 1802908-02-6

Tetrazine-PEG5-NHS ester?????? 1682653-80-0

Methyltetrazine-PEG5-NHS Ester??? 1802907-92-1

 

Thiol-PEG2-acid? 1379649-73-6

Thiol-PEG3-acid? 1347750-82-6

Thiol-PEG4-acid? 749247-06-1

Thiol-PEG6-acid? 1347750-77-9

Thiol-PEG8-acid? 866889-02-3

Thiol-PEG12-acid????????????? 1032347-93-5

Thiol-PEG3-Alcohol??? 56282-36-1

Thiol-PEG4-Alcohol??? 90952-27-5

Bis-PEG3-thiol???? 2781-02-4

Bis-PEG5-thiol???? 89141-22-0

 

Lipoamido-PEG4-acid??????? 1314378-10-3

Lipoamido-PEG8-acid??????? 1334172-70-1

Lipoamido-PEG2-alcohol?? 1674386-82-3

Lipoamido-PEG3-alcohol?? 1342764-64-0

Lipoamido-PEG3-Azide????? 890016-39-4

Lipoamide-PEG3-Mal???????? 1314378-19-2

 

Biotin-PEG3-Lipoamide????? 1311963-67-3

 

SPDP-PEG6-NHS ester???? 1818294-32-4

 

Fmoc-N-amido-PEG2-acid??????? 872679-70-4

Fmoc-N-amido-PEG3-acid??????? 867062-95-1

Fmoc-N-amido-PEG4-acid??????? 557756-85-1

Fmoc-N-amido-PEG5-acid??????? 882847-32-7

Fmoc-N-amido-PEG6-acid??????? 882847-34-9

Fmoc-N-amido-PEG8-acid??????? 756526-02-0

Fmoc-N-amido-PEG9-acid??????? 1191064-81-9

Fmoc-N-amido-PEG12-Acid????? 756526-01-9

 

 

(+)-Biotin-PEG2-CH2CH2NH2??? 138529-46-1

(+)-Biotin-PEG3-CH2CH2NH2??? 359860-27-8

(+)-Biotin-PEG4-CH2CH2NH2??? 663171-32-2

(+)-Biotin-PEG6-CH2CH2NH2??? N/A

(+)-Biotin-PEG11-CH2CH2NH2? N/A

(+)-Biotin-PEG2-CH2CH2COOH N/A

(+)-Biotin-PEG3-CH2CH2COOH 252881-76-8

(+)-Biotin-PEG4-CH2CH2COOH 721431-18-1

(+)-Biotin-PEG6-CH2CH2COOH N/A

(+)-Biotin-PEG12-CH2CH2COOH????? N/A

(+)-Biotin-PEG2-NHS Ester 596820-83-6

m-PEG2-Azide

m-PEG3-Azide

m-PEG4-Azide

m-PEG6-Azide

m-PEG7-Azide

m-PEG8-Azide

單分散修飾性PEG、小分子量PEG介紹

單分散修飾性PEG、小分子量PEG介紹

聚乙二醇化技術(PEGylation)是一種先進的藥用大分子修飾技術。聚乙二醇分子與藥物分子連接,能夠增大藥物的相對分子量,達到延長藥效,降低毒性,增大藥物的水溶性等效果,聚乙二醇化技術(PEGylation)是改善藥物臨床效果的重要手段。

Monodisperse PEG(單分散修飾性PEG)的產品一般是由2個、3個、4個PEG重復單元組成的一種小分子單分散的純的PEG試劑,這類產品的整體分子量較小,他們的分子量的大小跟PEG的重復個數有關,個數越多分子量越大,由于此產品是重復單元的PEG屬于小分子單體,可以用純度來標明其質量的好壞,西安瑞禧生物生產的這種產品整體純度一般是95%+以上。該類小分子聚合物的重復單元一般從1個到24個之間不等,PEG二邊也常常存在的不同的基團,比如說羧基COOH,NH2氨基,N3疊氮,巰基SH等不同基團。當然由于該類產品是純的小分子,大部分產品都對應的有自己的CAS號。

小分子聚乙二醇(PEG)鏈接劑,可用于修飾各類生物藥物,通過正離子親脂類脂質體納米顆粒形成配方材料,將可能即時裝載靶向分子、實現對任何藥物的掛載,可為建立針對腫瘤患者的個性化治療藥物庫提供成熟的技術支持。

單分散短鏈小分子PEG

修飾性PEG品牌:金畔生物、Laysan Bio、Nanocs、Sunbio

polymer PEG衍生物產品一般是指以聚合物的聚乙二醇為原料,通過各種化學鍵反應,使得聚合物PEG二邊連上不同的活性基團,該類的產品的分子量都比較大,主要也取決于PEG的分子量的大學,比如說PEG分子量1000,那整體分子量就是1000多一點,如果PEG分子量是2000就是2000多一點,另外整體也看連接的基團,比如說PEG分子量是2000 ,他連接了DSPE這個基團,那整體分子量就是2800,如果連接了MAL或者NH2這樣的基團,這題分子量就是2100多,該類產品的質量不能按純度來衡量,因而PEG是聚合物,整個產品都是有一個分子量的分布的,所以該產品應該屬于混合物,我們衡量其質量一般看2個指標一個是PDI值,一個是取代率純度或者叫接枝率,PID值越小PEG的分布越窄,質量越好,取代率純度或接枝率越高 說明活性基團和PEG的鏈接率越高。該類產品沒有固定的CAS號 因為是聚合物。

另外還有一種polymer PEG產品是由二種或者2種以上的聚合物鏈接而成的,我們常常叫嵌段共聚物,A聚合物、B聚合物、C聚合物,我們常見的形式有A-B-A,B-A-B, A-B-C,A-B-C-A

等等,這類產品我們常用的聚合物一般有PEG、PLGA、PLA、PCL、PEI、PLL等等不同產品,往往可以在不同聚合物末端帶有不同的活性基團比如說MAL/NHS/COOH等等。

單分散修飾性PEG、小分子量PEG介紹

Monodisperse PEG小分子PEG產品列表:

Amine-PEG2-Acid??? 791028-27-8 ? ?氨基PEG羧基,氨基聚乙二醇羧基

Amine-PEG3-Acid??? 784105-33-5

Amine-PEG4-Acid??? 663921-15-1

Amine-PEG6-Acid??? 905954-28-1

Amine-PEG8-Acid??? 756526-04-2

 

Thiol-PEG4-Acid? 749247-06-1

Thiol-PEG5-Acid

Thiol-PEG8-Acid? 866889-02-3

Thiol-PEG12-Acid 1032347-93-5

 

MAL-PEG2-Acid?? ?756525-98-1

MAL-PEG3-Acid??? 518044-40-1

MAL-PEG4-Acid??? 518044-41-2

MAL-PEG5-Acid??? 1286755-26-7

MAL-PEG6-Acid??? 518044-42-3

MAL-PEG8-Acid??? 1818294-46-0

 

Azido-PEG2-Azide????? 1379365-47-5

Azido-PEG3-azide????? 101187-39-7

Azido-PEG4-Azide????? 182760-73-2

Azido-PEG5-Azide????? 356046-26-9

 

Biotin-PEG2-Acid??????? 1365655-89-5

Biotin-PEG3-acid??????? 252881-76-8

Biotin-PEG4-Acid??????? 721431-18-1

Biotin-PEG6-Acid??????? 1352814-10-8

Biotin-PEG12-Acid????? 1621423-14-0

 

Fmoc-NH-PEG2-CH2COOH???? 166108-71-0

Fmoc-NH-PEG2-CH2COOH???? 166108-71-0

Fmoc-NH-PEG3-CH2COOH???? 139338-72-0

Fmoc-NH-PEG4-CH2CO2H????? 437655-95-3

Fmoc-NH-PEG5-CH2COOH???? 635287-26-2

Fmoc-NH-PEG8-CH2COOH???? 868594-52-9

 

Fmoc-PEG4-NHS ester???? 1314378-14-7

Fmoc-PEG6-NHS ester???? 1818294-31-3

Fmoc-PEG8-NHS ester???? 1334170-03-4

 

t-Boc-N-amido-PEG2-acid???????? 1365655-91-9

t-Boc-N-amido-PEG3-acid???????? 1347750-75-7

t-Boc-N-amido-PEG4-acid???????? 756525-91-4

t-Boc-N-amido-PEG5-acid???????? 1347750-78-0

t-Boc-N-amido-PEG6-acid???????? 882847-13-4

t-Boc-N-amido-PEG8-acid???????? 1334169-93-5

t-Boc-N-amido-PEG12-acid?????? 187848-68-6

 

t-Boc-N-amido-PEG2-Amine???? 153086-78-3

t-Boc-N-Amido-PEG3-Amine???? 101187-40-0

t-Boc-N-amido-PEG4-Amine???? 811442-84-9

t-boc-N-amido-PEG5-Amine???? 189209-27-6

t-Boc-N-amido-PEG6-Amine???? 1091627-77-8

t-boc-N-amido-PEG7-Amine???? 206265-98-7

t-Boc-N-amido-PEG9-Amine???? 890091-43-7

t-Boc-N-amido-PEG11-Amine?? 890091-42-6

 

t-Boc-N-Amido-PEG2-Azide????? 950683-55-3

t-Boc-N-Amido-PEG3-Azide????? 642091-68-7

t-Boc-N-Amido-PEG4-Azide????? 940951-99-5

t-boc-N-amido-PEG5-Azide????? 189209-27-6

 

mPEG2-NH2? 31576-51-9

mPEG3-NH2? 74654-07-2

mPEG4-NH2? 85030-56-4

mPEG6-NH2? 5498-83-9

mPEG8-NH2? 184357-46-8?? 170572-38-0? 211859-73-3

mPEG9-NH2

mPEG10-NH2??? 854601-60-8

mPEG12-NH2??? 869718-87-6

 

mPEG3-COOH?? 67319-28-2

mPEG4-COOH?? 81836-43-3

mPEG5-COOH

mPEG6-COOH?? 874208-91-0

mPEG7-COOH?? 1093647-41-6

 

mPEG3-SH?? 31521-83-2

mPEG4-SH?? 52190-55-3??? 524030-00-0

mPEG6-SH?? 441771-60-4

mPEG8-SH?? 651042-83-0

mPEG9-SH?? 651042-84-1

mPEG10-SH? 651042-85-2

SPDP-PEG3-acid??????? 1334177-97-7

SPDP-PEG6-acid??????? 1818294-33-5

 

Biotin-PEG3-alcohol??? 1263044-40-1

Biotin-PEG4-alcohol??? 1778736-18-7

Biotin-PEG6-alcohol??? 906099-89-6

 

Biotin-PEG4-Alkyne??? 1458576-00-5

 

Biotin-PEG2-Amine???? 138529-46-1

Biotin-PEG3-Amine???? 359860-27-8

Biotin-PEG4-Amine???? 663171-32-2

Biotin-PEG5-Amine???? 113072-75-6

 

Biotin-PEG2-Azide

Biotin-PEG3-Azide????? 945633-30-7

Biotin-PEG4-Azide????? 875770-34-6

Biotin-PEG5-azide????? 1163732-89-5

Biotin-PEG7-Azide????? 1334172-75-6

 

NH2-PEG3-NH2??? 929-75-9

NH2-PEG4-NH2??? 68960-97-4

NH2-PEG5-NH2??? 72236-26-1

NH2-PEG6-NH2

NH2-PEG7-NH2

NH2-PEG8-NH2??? 822096-36-7

NH2-PEG9-NH2

NH2-PEG10-NH2??? 928292-69-7

 

 

HOOC-PEG3-COOH??? 31127-85-2

HOOC-PEG4-COOH??? 439114-13-3

HOOC-PEG6-COOH??? 94376-75-7

 

HO-PEG6-COOH?? 1347750-85-9

HO-PEG8-COOH?? 937188-60-8

 

MAL-PEG2-NHS??? 1433997-01-3

MAL-PEG3-NHS??? 1537892-36-6

MAL-PEG4-NHS??? 1325208-25-0

MAL-PEG5-NHS??? 1807537-42-3

MAL-PEG6-NHS???? 1599472-25-9

 

H2N-PEG3-OH?? 86770-74-3

H2N-PEG4-OH

H2N-PEG5-OH?? 34188-11-9

H2N-PEG6-OH?? 39160-70-8

H2N-PEG7-OH?? 1425973-14-3

H2N-PEG8-OH?? 352439-37-3

H2N-PEG12-OH?? 933789-97-0

 

N3-PEG2-NH2?? 166388-57-4

N3-PEG3-NH2?? 134179-38-7

N3-PEG4-NH2?? 951671-92-4

N3-PEG5-NH2?? 516493-93-9

N3-PEG6-NH2?? 957486-82-7

N3-PEG7-NH2? 1333154-77-0

N3-PEG8-NH2? 857891-82-8

N3-PEG10-NH2? 912849-73-1

 

N3-PEG2-NHS?? 29885-96-9

N3-PEG3-NHS?? 1245718-89-1

N3-PEG4-NHS?? 944251-24-5

N3-PEG5-NHS?? 1433996-86-1

N3-PEG8-NHS?? 1204834-00-3

N3-PEG12-NHS? 1610796-02-5

 

N3-PEG2-OH??? 139115-90-5

N3-PEG3-OH??? 86520-52-7

N3-PEG4-OH??? 86770-67-4

N3-PEG5-OH?? 86770-68-5

N3-PEG6-OH?? 86770-69-6

 

N3-PEG2-COOH? 1312309-63-9

N3-PEG3-COOH? 172531-37-2

N3-PEG4-COOH? 1257063-35-6

N3-PEG5-COOH? 1425973-16-5

N3-PEG6-COOH? 361189-66-4

N3-PEG8-COOH? 1214319-92-2

N3-PEG10-COOH? 1644163-57-4

N3-PEG12-COOH ?1167575-20-3

 

Biotin-PEG2-NH2? 138529-46-1

Biotin-PEG3-NH2? 359860-27-8

Biotin-PEG4-NH2?? 138529-46-1

Biotin-PEG5-NH2?? 113072-75-6

Biotin-PEG6-NH2?? 663171-32-2

Biotin-PEG7-NH2?? 1334172-76-7

 

Biotin-PEG2-COOH ??1365655-89-5

Biotin-PEG3-COOH ???252881-76-8

Biotin-PEG4-COOH?? 721431-18-1

Biotin-PEG6-COOH?? 1352814-10-8

Biotin-PEG8-COOH

Biotin-PEG12-COOH?? 1621423-14-0

 

Biotin-PEG3-NHS??? 596820-83-6

Biotin-PEG3-NHS??? 1253286-56-4

Biotin-PEG4-NHS??? 459426-22-3

Biotin-PEG6-NHS

Biotin-PEG8-NHS

Biotin-PEG12-NHS?? 365441-71-0

Biotin-PEG20-NHS

Biotin-PEG24-NHS

 

Biotin-PEG3-N3?? 945633-30-7

Biotin-PEG4-N3?? 875770-34-6

Biotin-PEG5-N3?? 1163732-89-5

Biotin-PEG7-N3?? 1334172-75-6

 

Biotin-PEG2-MAL? 305372-39-8

Biotin-PEG3-MAL? 1431618-70-0

Biotin-PEG6-MAL? 1808990-66-0

 

Biotin-PEG4-Alkyne? 1458576-00-5

 

Fluorescein-PEG4-Acid?? 1807518-76-8

Fluorescein-PEG6-Acid

Fluorescein-PEG3-Amine? 1807539-04-3

Fluorescein-PEG2-Azide?? 1146195-72-3

Fluorescein-PEG3-(N-Boc)-Amine?? 1807534-77-5

Fluorescein-PEG6-NHS ester?????? 1818294-35-7

TAMRA-PEG3-Azide??? 1228100-59-1

TAMRA-PEG4-Alkyne?? 1225057-68-0

TAMRA-Azide-PEG-Biotin

TAMRA-PEG4-DBCO

Pyrene -PEG4-acid

Pyrene -PEG2-azide

Cy5-PEG4-acid

 

Mal-PEG2-PFP??? 1807512-47-5

Mal-PEG3-PFP??? 1807534-78-6

Mal-PEG4-PFP??? 1415800-42-8

Mal-PEG5-PFP??? 1807512-46-4

Mal-PEG6-PFP??? 1599486-33-5

 

Azide-PEG3-Tos? 178685-33-1

Azide-PEG4-Tos? 236754-49-7

Azide-PEG5-Tos? 236754-49-7

 

Hydroxy-PEG3-Tos?????? 77544-68-4

Hydroxy-PEG4-Tos?????? 77544-68-4

Hydroxy-PEG5-Tos?????? 77544-60-6

Hydroxy-PEG6-Tos?????? 155130-15-7

 

Propargyl-PEG4-Tos?? 875770-32-4

Propargyl-PEG5-Tos?? 875770-32-4

 

Azido-PEG3-Maleimide

 

Bromo-PEG2-azide???? 530151-56-5

Bromo-PEG3-azide???? 940005-81-2

Bromo-PEG5-azide???? 1415800-37-1

 

Azido-PEG2-TFP ester????? 1807534-87-7

Azido-PEG3-TFP ester????? 1807540-76-6

Azido-PEG4-TFP ester????? 1807505-33-4

Azido-PEG5-TFP ester????? 1807505-31-2

Azido-PEG6-TFP ester????? 1818294-50-6

Azido-PEG8-TFP ester????? 1818294-49-3

 

Azido-PEG2-PFP ester????? 1393330-37-4

Azido-PEG3-PFP ester????? 1807530-07-9

Azido-PEG4-PFP ester????? 1353012-00-6

Azido-PEG5-PFP ester????? 1818294-48-2

Azido-PEG6-PFP ester????? 1818294-47-1

 

DBCO-PEG4-acid?????? 1537170-85-6

DBCO-PEG5-Acid

DBCO-PEG4-Alcohol

DBCO-amine??????? 1255942-06-3

DBCO-PEG4-amine??? 1255942-08-5

DBCO-PEG4-Biotin???? 1255942-07-4

DBCO-PEG4-Maleimide???? 1480516-75-3

DBCO-PEG4-NHS ester??? 1427004-19-0

DBCO-PEG5-NHS ester??? 1378531-80-6

 

DNP-PEG2-acid?? 1353011-89-8

DNP-PEG4-acid?? 858126-76-8

DNP-PEG6-acid?? 1817829-84-7

DNP-PEG4-NHS ester?????? 858126-78-0

 

propargyl-PEG3-Acid? 1347760-82-0

Propargyl-PEG4-acid? 1415800-32-6

propargyl-PEG5-Acid? 1245823-51-1

 

Propargyl-PEG2-amine????? 944561-44-8

Propargyl-PEG3-amine????? 932741-18-9

Propargyl-PEG4-amine????? 1013921-36-2

Propargyl-PEG5-amine????? 1589522-46-2

Propargyl-PEG6-amine????? 1198080-04-4

 

Propargyl-PEG3-azide????????????? 932741-18-9

 

Propargyl-PEG4-Maleimide?????? 1609651-90-2

 

Propargyl-PEG3-NHS ester????? 1428629-71-3

Propargyl-PEG4-NHS ester????? 1428629-70-2

Propargyl-PEG5-NHS ester????? 1393330-40-9

 

DBCO-PEG4-Biotin???? 1255942-07-4

 

Biotin-PEG3-hydrazide????? 1381861-94-4

 

Bis-PEG2-acid???? 19364-66-0

Bis-PEG3-acid???? 96517-92-9

Bis-PEG4-acid???? 31127-85-2

Bis-PEG5-acid???? 439114-13-3

Bis-PEG7-acid???? 94376-75-7

Bis-PEG9-acid???? 1268488-70-5

 

Acid-PEG5-NHS ester????????????? 1343476-41-4

 

Bis-PEG2-NHS Ester???????? 65869-63-8

Bis-PEG3-NHS Ester???????? 1314378-16-9

Bis-PEG4-NHS ester???????? 1314378-11-4

Bis-PEG5-NHS ester???????? 756526-03-1

Bis-PEG6-NHS ester???????? 1526718-98-8

Bis-PEG7-NHS ester???????? 1334170-02-3

 

TCO-PEG4-Acid???????? 1802913-21-8

TCO-PEG3-Maleimide?????? 1609659-01-9

TCO-NHS ester????????? 1191901-33-3

TCO-PEG4-NHS ester?????? 1613439-69-2

 

Hydroxy-PEG2-acid??? 1334286-77-9

Hydroxy-PEG3-acid??? 518044-49-0

Hydroxy-PEG4-acid??? 937188-59-5

Hydroxy-PEG6-acid??? 1347750-85-9

Hydroxy-PEG8-t-butyl ester????? 937188-60-8

 

Amino-PEG3-alcohol?? 6338-55-2

Amino-PEG4-alcohol?? 86770-74-3

Amino-PEG5-alcohol?? 34188-11-9

Amino-PEG6-alcohol?? 39160-70-8

Amino-PEG7-alcohol?? 1425973-14-3

Amino-PEG8-alcohol?? 352439-37-3

Amino-PEG12-alcohol 933789-97-0

 

Methyltetrazine-PEG4-Acid?????? 1802907-91-0

Methyltetrazine-PEG5-Alkyne?? 1802907-97-6

Methyltetrazine-PEG4-Amine??? 1802908-05-9

Biotin-PEG4-Methyltetrazine???? 1835759-81-3

Methyltetrazine-PEG4-Maleimide???? 1802908-02-6

Tetrazine-PEG5-NHS ester?????? 1682653-80-0

Methyltetrazine-PEG5-NHS Ester??? 1802907-92-1

 

Thiol-PEG2-acid? 1379649-73-6

Thiol-PEG3-acid? 1347750-82-6

Thiol-PEG4-acid? 749247-06-1

Thiol-PEG6-acid? 1347750-77-9

Thiol-PEG8-acid? 866889-02-3

Thiol-PEG12-acid????????????? 1032347-93-5

Thiol-PEG3-Alcohol??? 56282-36-1

Thiol-PEG4-Alcohol??? 90952-27-5

Bis-PEG3-thiol???? 2781-02-4

Bis-PEG5-thiol???? 89141-22-0

 

Lipoamido-PEG4-acid??????? 1314378-10-3

Lipoamido-PEG8-acid??????? 1334172-70-1

Lipoamido-PEG2-alcohol?? 1674386-82-3

Lipoamido-PEG3-alcohol?? 1342764-64-0

Lipoamido-PEG3-Azide????? 890016-39-4

Lipoamide-PEG3-Mal???????? 1314378-19-2

 

Biotin-PEG3-Lipoamide????? 1311963-67-3

 

SPDP-PEG6-NHS ester???? 1818294-32-4

 

Fmoc-N-amido-PEG2-acid??????? 872679-70-4

Fmoc-N-amido-PEG3-acid??????? 867062-95-1

Fmoc-N-amido-PEG4-acid??????? 557756-85-1

Fmoc-N-amido-PEG5-acid??????? 882847-32-7

Fmoc-N-amido-PEG6-acid??????? 882847-34-9

Fmoc-N-amido-PEG8-acid??????? 756526-02-0

Fmoc-N-amido-PEG9-acid??????? 1191064-81-9

Fmoc-N-amido-PEG12-Acid????? 756526-01-9

 

 

(+)-Biotin-PEG2-CH2CH2NH2??? 138529-46-1

(+)-Biotin-PEG3-CH2CH2NH2??? 359860-27-8

(+)-Biotin-PEG4-CH2CH2NH2??? 663171-32-2

(+)-Biotin-PEG6-CH2CH2NH2??? N/A

(+)-Biotin-PEG11-CH2CH2NH2? N/A

(+)-Biotin-PEG2-CH2CH2COOH N/A

(+)-Biotin-PEG3-CH2CH2COOH 252881-76-8

(+)-Biotin-PEG4-CH2CH2COOH 721431-18-1

(+)-Biotin-PEG6-CH2CH2COOH N/A

(+)-Biotin-PEG12-CH2CH2COOH????? N/A

(+)-Biotin-PEG2-NHS Ester 596820-83-6

m-PEG2-Azide

m-PEG3-Azide

m-PEG4-Azide

m-PEG6-Azide

m-PEG7-Azide

m-PEG8-Azide